Talk:Cholesterol

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No Physical Properties or Characteristics provided

Like normal form, specific gravity, ability to withstand heat, melting and boiling points, breakdown temperatures, etc. — Preceding unsigned comment added by 2409:4071:220D:7281:3CD0:68FF:FE7F:8333 (talk) 12:09, 17 March 2024 (UTC)[reply]

What about this research?

LDL-C does not cause cardiovascular disease: a comprehensive review of the current literature

Link: https://www.tandfonline.com/doi/full/10.1080/17512433.2018.1519391 Nemohuman (talk) 08:35, 10 March 2024 (UTC)[reply]

Blatant pseudoscience. The authors of the paper work for the THINCS organization. The same authors published another review which has been discredited [1], [2], [3]. They basically argue that elderly people with lower LDL-c have an increased mortality risk. This isn't a controversial finding it is well known, it's because the elderly people studied have increased risk of chronic disease like cancer and this is known to lower cholesterol. It is a case of reverse causality. It is not evidence that high LDL-c is beneficial for health. There is strong evidence that LDL-c causes cardiovascular disease [4]. Psychologist Guy (talk) 16:45, 10 March 2024 (UTC)[reply]

Biosynthesis to be contracted

I propose to remove most of the biosynthesis section, which begins with very early, almost generic steps. Instead the biosynthesis can begin with lanosterol.--Smokefoot (talk) 14:37, 13 August 2024 (UTC)[reply]

the claim "Biosynthesis in all cells" to be deleted

In multiple location the page claims that cholesterol is made in all cells, but there is no citation. Furthermore, it is well accepted that neurons do not make cholesterol. And almost all studies show that cholesterol is transported in the blood and then taken up into cells through receptor mediated endocytosis. The mere presence of the enzymes that metabolize cholesterol is not evidence that the cells make cholesterol. Advocates for ubiqitous cholesterol synthesis need to produce evidence that the cholesterol is actually produced in the various cell types rather than taken up.

Lastly, given the large amounts of cholesterol that are taken up by cells from the blood. Some rational as to why the cells would be making cholesterol when there enormous quantities made available every day in the blood needs to be addressed. The data suggests most cells in the body don't make appreciable amounts of cholesterol and the uptake of the cholesterol from the blood or astrocytes dictates the important biological function of cholesterol, not individual cellular synthesis. If there is a biological process known, in a non-hepatic cell, where individual cellular synthesis drives a biological function, please indicate. All the known biological functions of cholesterol, including cholesterol related diseases, is driven by uptake from the blood not synthesis within the affected cells. — Preceding unsigned comment added by PhD2005 (talk • contribs) 03:43, 21 October 2024 (UTC)[reply]

Neurons do synthesize cholesterol.^[1]^[2]. On the other hand, many organisms appear to have lost the ability to synthesize cholesterol through evolution.^[3] Nevertheless, humans definitively do synthesize cholesterol.^[4]

References

^ Zhang J, Liu Q (April 2015). "Cholesterol metabolism and homeostasis in the brain". Protein & Cell. 6 (4): 254–64. doi:10.1007/s13238-014-0131-3. PMC 4383754. PMID 25682154.
^ Fünfschilling U, Jockusch WJ, Sivakumar N, Möbius W, Corthals K, Li S, Quintes S, Kim Y, Schaap IA, Rhee JS, Nave KA, Saher G (May 2012). "Critical time window of neuronal cholesterol synthesis during neurite outgrowth". The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 32 (22): 7632–45. doi:10.1523/JNEUROSCI.1352-11.2012. PMC 6703588. PMID 22649242.
^ Shamsuzzama, Lebedev R, Trabelcy B, Langier Goncalves I, Gerchman Y, Sapir A (August 2020). "Metabolic Reconfiguration in C. elegans Suggests a Pathway for Widespread Sterol Auxotrophy in the Animal Kingdom". Current Biology : CB. 30 (15): 3031–3038.e7. doi:10.1016/j.cub.2020.05.070. PMID 32559444. {{cite journal}}: no-break space character in |title= at position 32 (help)
^ "Cholesterol Biosynthesis".

"Cholesterol is biosynthesized by all animal cells" is blatantly untrue

Without even getting into different cell types, most insects can't biosynthesize cholesterol at all. To be clear, they still require sterols, but they must obtain said sterols through their diet.

Here's a review article explaining that most protostomes lack the ability to synthesize cholesterol, not just insects. 198.137.18.219 (talk) 20:05, 6 February 2025 (UTC)[reply]

[pmid25682154-1] Zhang J, Liu Q (April 2015). "Cholesterol metabolism and homeostasis in the brain". Protein & Cell. 6 (4): 254–64. doi:10.1007/s13238-014-0131-3. PMC 4383754. PMID 25682154.

[pmid22649242-2] Fünfschilling U, Jockusch WJ, Sivakumar N, Möbius W, Corthals K, Li S, Quintes S, Kim Y, Schaap IA, Rhee JS, Nave KA, Saher G (May 2012). "Critical time window of neuronal cholesterol synthesis during neurite outgrowth". The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 32 (22): 7632–45. doi:10.1523/JNEUROSCI.1352-11.2012. PMC 6703588. PMID 22649242.

[pmid32559444-3] Shamsuzzama, Lebedev R, Trabelcy B, Langier Goncalves I, Gerchman Y, Sapir A (August 2020). "Metabolic Reconfiguration in C. elegans Suggests a Pathway for Widespread Sterol Auxotrophy in the Animal Kingdom". Current Biology : CB. 30 (15): 3031–3038.e7. doi:10.1016/j.cub.2020.05.070. PMID 32559444. {{cite journal}}: no-break space character in |title= at position 32 (help)

[4] "Cholesterol Biosynthesis".

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